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C1酯酶抑制劑

 發(fā)布時間:2018/7/30 點擊量:1203

 

Athens Research & Technology自1986年以來一直在凈化人類蛋白質(zhì)和開發(fā)這些蛋白質(zhì)的多克隆抗血清。我們專注于高純度,高活性的人類蛋白質(zhì)。我們常規(guī)純化絲氨酸蛋白酶,蛋白酶抑制劑,中性粒細胞酶,載脂蛋白,脂蛋白,血小板蛋白,轉(zhuǎn)鐵蛋白,免疫球蛋白等。世界各地的研究人員已經(jīng)從我們這里購買了這些研究試劑超過二十五年。您將看到我們的產(chǎn)品在炎癥,冠心病,自身免疫性疾病,癌癥,阿爾茨海默病等研究的主要科學(xué)出版物中被引用。

我們還從動物血清和組織中分離蛋白質(zhì)。

我們的產(chǎn)品被診斷和制藥行業(yè)的先進者用作體外診斷和免疫測定試劑盒的組分,以及細胞培養(yǎng)基,包括支持干細胞的培養(yǎng)基。雅典研究和技術(shù)的蛋白質(zhì)也被開發(fā)生物治療藥物的研究人員用于概念驗證研究。

 

C1酯酶抑制劑,人血漿

產(chǎn)品編號:

16-16-031509

 

MW:100,000 
消光系數(shù):0.4

用含有250mMpotassium phosphate的20mM磷酸鉀(pH7.0)冷凍

儲存:-70°C或更低

購買純化的天然人C1酯酶抑制劑,人血漿。
批量數(shù)量可用。

單鏈糖蛋白,抑制C1,C1r,C1s,血漿激肽釋放酶,因子XIa。XIIa和纖溶酶。以每100毫升16-33毫克存在于血漿中。C1酯酶抑制劑缺乏是一種罕見的病癥,導(dǎo)致面部腫脹和腹部絞痛。通常情況是遺傳性的,盡管它也可能在C1EI無功能時發(fā)生。

純度:通過SDS-PAGE> = 95%

同義詞:補體C1酯酶抑制劑,酯酶抑制劑C-1

通過FDA批準的測試,血漿制備顯示對HbsAG,抗-HCV,抗-HBc無反應(yīng),對抗-HIV 1和2呈陰性。

雅典研究與技術(shù)產(chǎn)品是實驗室試劑,不得用于人體或用于任何藥物目的。僅供研究或進一步制造使用。

產(chǎn)品引用:

Salvesen,GS等人。1985. J. Biol?;瘜W(xué)。260,2432。

Lee,Kyoung Geun,Haneulnari Lee,Jeong Mi Ha,Young Kyung Lee,Hee Jung Kang,Chung-Gyu Park和Sang Joon Kim。“增加的人腫瘤壞死因子-α水平在體外誘導(dǎo)豬內(nèi)皮細胞的促凝血改變。”異種移植19,沒有。3(2012):186-195

Kang,Hee Jung,Haneulnari Lee,Jeong-mi Ha,Jae-il Lee,Jun-Seop Shin,Ki-Yong Kim,Ji Yoon Park et al。“替代補體途徑在門靜脈內(nèi)豬胰島異種移植后早期移植物丟失中的作用。” 移植(2014年)

Kenninston JA,et al。高特異性活性位點阻斷抗體對血漿激肽釋放酶的抑制作用。J Biol Chem。2014年8月22日; 289(34):23596-608。doi:10.1074 / jbc.M114.569061。Epub 2014年6月26日。

Zamolodchikov D,Renner T,Strickland S. 
阿爾茨海默氏病肽β-淀粉樣蛋白通過激活凝血因子XII促進凝血酶的產(chǎn)生。
J Thromb Haemost。2016年5月; 14(5):995-1007。doi:10.1111 / jth.13209。Epub 
2016年2月29日。

 

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